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NEJM This Week


Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.


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Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.




NEJM This Week — December 7, 2023

Featuring articles on sotorasib plus panitumumab in KRAS-mutated colorectal cancer, baricitinib and β-cells in new-onset type 1 diabetes, teplizumab in youth with new-onset type 1 diabetes, and mirvetuximab soravtansine in FRα-positive, platinum- resistant ovarian cancer; a review article on waterborne disease sensitivity to climate change; a Clinical Problem-Solving on collecting puzzle pieces; and we introduce a new series on Historical Injustices in Medicine and the Journal with our first Perspective article on Slavery and the Journal.


NEJM This Week — November 30, 2023

Featuring articles on levothyroxine for unstable brain-dead heart donors, amivantamab in lung cancer with EGFR exon 20 insertions, amikacin to prevent ventilator-associated pneumonia, and tarlatamab in small-cell lung cancer, a new series on wearable digital health technology with a review article on digital technology for diabetes; a case report of a man with sickle cell disease and right hip pain; and Perspectives on coverage for emerging technologies, on methadone clinic engagement and cancer care, and on learning from the bomb.


NEJM This Week — November 23, 2023

Featuring articles on osimertinib and chemotherapy in EGFR-mutated non–small-cell lung cancer, transcatheter aortic-valve replacement in low-risk patients at five years, erdafitinib or chemotherapy in urothelial carcinoma, and liver transplantation for Mahvash disease; a review article on postmenopausal osteoporosis; a case report of a man with diabetes and kidney cysts; and Perspectives on opening the door to international medical graduates, on community-engaged research, and on woman, life, freedom.


NEJM This Week — November 16, 2023

Featuring articles on selpercatinib in RET fusion–positive NSCLC, selpercatinib in RET-mutant medullary thyroid cancer, gantenerumab in early Alzheimer’s disease, and stimulated copeptin to diagnose AVP deficiency; a review article on liver transplantation; a case report of a woman with waxing and waning pulmonary nodules; and Perspective articles on Rift Valley fever, on implanting a recalled device, and on biopsies from healthy volunteers in precision medicine.


NEJM This Week — November 9, 2023

Featuring articles on genetic variation and life span in Iceland, botulinum toxin for head tremor, decolonization in nursing homes to prevent infection, nivolumab plus chemotherapy in urothelial carcinoma, pembrolizumab in pregnancy, and on after affirmative action; a review article on catatonia; a case report of a woman with loss of consciousness and thrombocytopenia; and Perspective articles on how the FDA should evaluate psychedelic medicine, on federal oversight of laboratory-developed tests, and on the corporate divorce between two major Boston medical institutions.


NEJM This Week — November 2, 2023

Featuring articles on thalidomide for recurrent bleeding due to small-intestinal angiodysplasia, pulsed field ablation for paroxysmal atrial fibrillation, perioperative chemoimmunotherapy in lung cancer, and corin and cardiac phenotypes; a review article on cystic fibrosis; a Clinical Problem-Solving on being encased in peril; and Perspective articles on minimum-staffing rules for U.S. nursing homes, on reforming pharmacy benefit managers, on scaling up point-of-care fentanyl testing, and on familiar shadows.


NEJM This Week — October 26, 2023

Featuring articles on patisiran for transthyretin cardiac amyloidosis, automated insulin delivery in pregnancy complicated by diabetes, nemolizumab for prurigo nodularis, convalescent plasma for Covid-19–induced ARDS, and debt collection in American medicine; a case report of a man with shortness of breath; and Perspective articles on climate, health, and equity under the Farm Bill; on indigenous health perspectives on the Lāhainā fires, on whether price negotiations delay cancer-drug launches, and on the standard of care.


NEJM This Week — October 19, 2023

Featuring articles on on enzalutamide and leuprolide in prostate cancer, optical coherence tomography (OCT)–guided versus angiography-guided PCI, vancomycin and cefazolin prophylaxis in arthroplasty, and on OCT and eye care; a review article on the syndrome of inappropriate antidiuresis; a case report of a woman with recurrent hemorrhagic pericardial effusion; and Perspective articles on Yellow Jack’s potential return to the American South; on wedding websites, free speech, and adverse drug effects; and on a chance to modernize health care behind bars.


NEJM This Week — October 12, 2023

Featuring articles on dexamethasone for TB meningitis in HIV-positive adults, the timing of complete revascularization after myocardial infarction, catheter ablation for advanced heart failure and AFib, ceftobiprole for Staph. aureus bacteremia, and on AlphaFold being recognized through a Lasker Award; a review article on Shiga toxin–producing E. coli and the hemolytic–uremic syndrome; a case report of a man with involuntary movements and unresponsiveness; and Perspective articles on whether pandemics ever end, on the new over-the-counter oral contraceptive pill, and on a reason to retire.


NEJM This Week — October 5, 2023

Featuring articles on sarilumab for relapsing polymyalgia rheumatica; modifiable risk factors, cardiovascular disease, and mortality; extracorporeal life support in cardiogenic shock; and esketamine vs. quetiapine for treatment-resistant depression; a review article on stem-cell aging and precancer evolution; a Clinical Problem-Solving on digging into the histology; and Perspective articles on preventing heat-related illness among outdoor workers, on countering the health disinformation machine, and on dismantling the overpolicing of Black medical trainees.


NEJM This Week — September 28, 2023

Featuring articles on anticoagulation and atrial high-rate episodes, tight blood-glucose control in patients in the ICU, increasing artemisinin-resistant malaria in Eritrea, the death of a patient after high-dose gene therapy, and on antiracist documentation practices; a review article on where medical statistics meets AI; a case report of a woman with confusion; and Perspective articles on affirmative action, population health, and hope; on threatening the global AIDS response; and on swimming.


NEJM This Week — September 21, 2023

Featuring articles on semaglutide for heart failure in patients with obesity, inhaled fluticasone furoate for treatment of Covid-19, a trial of solanezumab in preclinical Alzheimer’s disease, and targeting the BRAF pathway in pediatric glioma; a review article on the prevention of central line–associated bloodstream infections; a case report of a woman with abdominal distention and acute kidney injury; and Perspective articles on the new USPSTF mammography recommendations, on the ethics of abortion care advocacy, and on reducing the risks of nuclear war.


NEJM This Week — September 14, 2023

Featuring articles on ferric carboxymaltose for heart failure with iron deficiency, antibiotic prophylaxis in infants with vesicoureteral reflux, the FGF21 analogue pegozafermin in NASH, and mezigdomide in relapsed and refractory multiple myeloma; a review article on asthma in adults; a case report of a man with a rash; and Perspective articles on a doctrine in name only, on the accelerated approval program for cancer drugs, and on a shared mission.


NEJM This Week — September 7, 2023

Featuring articles on the GLP-1 receptor agonist orforglipron for obesity, PCI in older patients with myocardial infarction, DNA editing in T-cell acute lymphoblastic leukemia, and atezolizumab in alveolar soft part sarcoma; a review article on Wilson’s disease; a Clinical Problem-Solving on how it’s all in the timing; and Perspective articles on NIH policy changes regarding international research collaborations, on alleviating medical debt in the United States, and on mass masking without mandates.


NEJM This Week — August 31, 2023

Featuring articles on concizumab in hemophilia A or B with inhibitors, the timing of primary surgery for cleft palate, improved mass screening for nasopharyngeal carcinoma, gene editing for sickle cell disease, and on artificial sweeteners; a review article on informative artifacts in AI-assisted health care; a case report of a woman with celiac disease and upper gastrointestinal bleeding; and Perspective articles on Project NextGen, on gerineuropalliative care for patients with dementia, and on sexual and gender minority refugees.


NEJM This Week — August 24, 2023

Featuring articles on preventing cardiovascular disease in HIV infection, the effect of hemodiafiltration or hemodialysis on mortality in kidney failure, a new KRAS G12C inhibitor in solid tumors, and on partial artemisinin resistance in malaria parasites; a review article on protein-losing enteropathy; a case report of a girl with abdominal pain and an ovarian mass; and Perspective articles on the Supreme Court and diversity in medicine, on outbreaks in U.S. migrant detention centers, on turning CMS into a health technology assessment organization, and on the clinic that cried safe.


NEJM This Week — August 17, 2023

Featuring articles on vorasidenib for IDH-mutant low-grade glioma; a trial of dietary intervention for cognitive decline; omitting radiotherapy after breast-conserving surgery in luminal A breast cancer; gene therapy for the Crigler–Najjar syndrome; and on abortion counseling, liability, and the First Amendment; a review article on community-acquired pneumonia; a case report of a man with fever and foot pain; and Perspective articles on prioritizing mental health in the HIV/ AIDS response in Africa, on reducing health care’s climate impact, and on free and charitable clinics.


NEJM This Week — August 10, 2023

Featuring articles on neoadjuvant therapy for lung cancer, a phase 2 trial of retatrutide for obesity, systemic inflammation and normocytic anemia in DOCK11 deficiency, and on the social determinants of health; a review article on thrombocytopenia in pregnant women; a case report of a man with a pulmonary nodule; and Perspective articles on over-the-counter access to HIV preexposure prophylaxis, on preparing physicians for the clinical algorithm era, and on reading Kafka in the hospital cafeteria.


NEJM This Week — August 3, 2023

Featuring articles on a novel sodium channel blocker to treat acute pain, the effects of adult thymectomy, video vs. direct laryngoscopy for tracheal intubation, and on antidepressant maintenance in bipolar I depression; a review article on the neurologic consequences of preterm birth; a Clinical Problem-Solving on a race to the finish; and Perspective articles on AI and medical education, on expanding access to health care for DACA recipients, and on the freedom cure.


NEJM This Week — July 27, 2023

Featuring articles on weekly insulin icodec or daily glargine in type 2 diabetes, an orexin receptor 2 agonist in narcolepsy, neoadjuvant therapy for rectal cancer, and cilta-cel in lenalidomide-refractory multiple myeloma; a review article on artificial intelligence in U.S. health care delivery; a case report of a young man with progressive dyspnea; and Perspective articles on a critical opportunity to improve public health data, on the future of prior-authorization reform, and on curiosity in clinical care.