NBC Nightly News with Lester Holt

17-year-old Michigan mass shooter given multiple life sentences; FDA approves groundbreaking sickle cell anemia treatment; Global outrage after Palestinian men are stripped to their underwear by Israeli troops; and more on tonight’s broadcast.

Shots fired outside synagogue in Albany, suspect in custody; UNLV shooting suspect was career professor who was rejected from job, sheriff says; Freed Hamas hostage returns home to her devastated kibbutz; and more on tonight’s broadcast.

Multiple victims, suspect dead in University of Nevada, Las Vegas shooting; Suspect in custody after six people were killed in Austin and San Antonio; Deadly flooding in Pacific Northwest after relentless rain; and more on tonight’s broadcast.

Lester Holt anchors an NBC News Special Report as police respond to an active shooter situation at the University of Nevada, Las Vegas.

Growing evidence of Hamas’ sexual crimes against women during attack, Israeli investigators say; Millions in Pacific Northwest under flood alerts as multiple storms hit region; Zelenskyy aide says Ukraine faces risk of losing war without more U.S. military aid; and more on tonight’s broadcast.

As a bonus for you, we’re sharing the trailer for Mortal Sin, an all-new original podcast series from Dateline. Dawn and Nick Hacheney are the perfect couple: spiritual, loving, and devoted to the church where Nick is a pastor. When Dawn is killed in a house fire the day after Christmas, the pastor and his flock are devastated. What few knew at the time was the dark prophecy that foretold it. In Dateline’s latest original podcast series, Josh Mankiewicz tells a twisted tale about sex, lies, religion…and murder. Listen to the first 2 episodes now for free or subscribe to Dateline Premium on Apple Podcasts to get access to new episodes 1 week early. Subscribers can also listen to all Dateline podcasts ad-free: https://link.chtbl.com/mtlsin_fdlw

Israel expands ground offensive against Hamas in Gaza; White House condemns pro-Palestinian protest at Philadelphia restaurant as antisemitic; What we know about the mysterious illness hitting dogs; and more on tonight’s broadcast.

USS Carney responded after attacks on civilian ships in Red Sea, Defense officials confirm; Israel announces ground offensive into southern Gaza has begun; Man kills German tourist in knife attack near Eiffel Tower, police report; and more on tonight’s broadcast.

Israel has continued its attacks on Gaza, a suspected serial killer was caught in California after four people were killed over the course of four days and polar bears are invading a town in Canada at a record rate.

George Santos expelled from Congress after House vote; Fighting resumes in Gaza after cease-fire ends; Sandra Day O’Connor, first female Supreme Court justice, dies at 93; and more on tonight’s broadcast.

Cease-fire in Gaza will extend at least through tomorrow, Israeli military says; Mothers of college students shot in Vermont speak out about incident; House Republicans set to decide fate of Rep. George Santos tomorrow; and more on tonight’s broadcast.

American among 12 additional hostages released as cease-fire continues; Deadly U.S. Air Force Osprey crash off of Japan’s southern coast; Gas prices are down as U.S. oil production is back up to record levels; and more on tonight’s broadcast.

Lester Holt anchors an NBC News Special Report as an American hostage is released by Hamas.

12 more hostages released by Hamas; Millions of Americans hit with first winter blast; Alex Murdaugh sentenced to 27 years for financial crimes; and more on tonight’s broadcast.

Inside hostages’ 49 days of captivity while being held by Hamas; Suspect arraigned in shooting of three students of Palestinian descent in Vermont; China grappling with spike in respiratory illnesses, U.S. seeing rise in flu and RSV cases; and more on tonight’s broadcast.

Hamas releases first U.S. citizen as part of temporary cease-fire agreement; Authorities search for suspect who shot 3 Palestinian college students in Vermont; Sunday predicted to be biggest air travel day in U.S. history; and more on tonight’s broadcast.

More hostages released after the Israel-Hamas deal almost fell through, the police officer convicted of killing George Floyd was stabbed in prison and 14 million Americans are under winter weather alerts.

24 hostages released by Hamas after 49 days of captivity; Law enforcement cracking down on retail crimes this holiday shopping season; Behind the scenes with the Radio City Rockettes; and more on tonight’s broadcast.

Lester Holt anchors an NBC News Special Report as President Biden speaks on the hostages released by Hamas today.

Long-awaited hostage deal set to move ahead; Authorities looking into airline incidents amid Thanksgiving travel rush; Former Obama advisor caught on video berating NYC street vendor; and more on tonight’s broadcast.