Psychopharmacology and Psychiatry Updates

In this episode, we explore whether the olanzapine–samidorphan combination helps with psychosis while halting weight gain. We also look into the cost vs benefit of the combination as well as the metabolic side effects. Faculty: James Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 51Comparative Efficacy, Safety, and Acceptability of Pimavanserin and Other Atypical Antipsychotics for Parkinson’s Disease Psychosis: Systematic Review and Network Meta-Analysis

Can melatonin reduce the risk of suicidality, bodily injuries, falls, and accidents in children and adolescents? In this episode, we explore a study that delves into this question. Discover how sleep disturbances impact young individuals' health, development, cognitive skills, emotional regulation, and behavior. Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: CAP Smart Takes Vol. 11Melatonin Use and the Risk of Self-Harm and Unintentional Injuries in Youth

Do you know what sleep-related eating disorder (SRED) is and how it intertwines sleep and eating pathologically? In this episode, we delve into an in-depth analysis of SRED, elucidating its diagnostic criteria, key characteristics of the diagnosis, and some intriguing aspects related to this disorder. Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 0.5 CME: Parasomnias Triggered by Sedative-Hypnotics: Sleepwalking and Sleep Related Eating DisorderDiagnosing Sleep-Related Eating Disorder (SRED)

This episode explores the controversial role of pimavanserin in treating psychosis in Parkinson's disease. How does it compare with quetiapine or clozapine? Sneak peek: All of these medications are effective, yet none distinctly surpasses the others. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 51Comparative Efficacy, Safety, and Acceptability of Pimavanserin and Other Atypical Antipsychotics for Parkinson’s Disease Psychosis: Systematic Review and Network Meta-Analysis

Pediatric bipolar disorder treatment has evolved significantly since 2005, moving beyond lithium to several FDA-approved treatments. However, the challenges remain: How do we choose the first-line treatment? How can we mitigate and monitor side effects? In this episode, we discuss the latest practice treatment algorithms for pediatric bipolar disorder. Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: CAP Smart Takes Vol. 10Psychopharmacologic Treatment Algorithms for Bipolar Disorder in Youth

Can pharmacogenomic testing improve the selection and dosing of antidepressants in patients with MDD? In this episode, we explore the findings of the PRIME Care trial and discuss the clinical significance of these tests. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 49Effect of Pharmacogenomic Testing for Drug–Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial

In this episode, we discuss the role of broad-spectrum micronutrients (BSMs) in managing symptoms of ADHD. We examine the rationale behind opting for alternative therapies for this condition and dissect the outcomes of an RCT involving BSMs for ADHD. Could micronutrients provide a comprehensive strategy for treating ADHD, thereby enhancing overall mental wellness? Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 0.75 CME: Broad-Spectrum Micronutrients (BSM) for Mental Health: Context for Considering Micronutrient TreatmentAn Overview of Standard Treatment vs CAM for ADHD

Are you aware that a staggering 80% of ADHD patients report at least 1 side effect from their medication? In this episode, we discuss an analysis that seeks to answer an essential question: Can we predict medication nonadherence in adolescents and young adults with ADHD based on specific side effects? Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: CAP Smart Takes Vol. 10Reported Side Effects Associated With Medication Nonadherence Among Youth With ADHD

Did you know that your genes could affect how your brain processes vital nutrients? In this episode, we delve into fascinating research on micronutrient supplementation for mental disorders, such as ADHD. Discover how our genetic makeup might dictate our nutrient needs and how this can influence mental health outcomes. Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 0.75 CME: Broad-Spectrum Micronutrients (BSM) for Mental Health: Context for Considering Micronutrient TreatmentRationale for Micronutrient Supplementation in Mental Illness

Could antipsychotic switching impact substance use in schizophrenia? In this episode, Dr. Jim Phelps explores the impact of antipsychotics on patients with schizophrenia and substance use disorder. He includes insights from national cohorts and clinical cases and delves into the potential effects of changing from risperidone to clozapine. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 49Associations Between Antipsychotic Use, Substance Use, and Relapse Risk in Patients with Schizophrenia: Real-World Evidence From 2 National Cohorts

Dive into the fascinating world of nutrition's impact on mental health in our latest episode. We explore intriguing studies on the Mediterranean diet's potential to alleviate depressive symptoms. Can a shift in dietary habits truly improve mental health? Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 0.75 CME: Broad-Spectrum Micronutrients (BSM) for Mental Health: Context for Considering Micronutrient TreatmentDepression and Mediterranean-Style Diet

In this episode, we explore a pressing problem in pediatric psychiatry: The disparities in the use of pharmacologic restraints. How can we address these biases in our healthcare system? What role do behavioral interventions play in reducing the need for these measures? Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: CAP Smart Takes Vol. 09Disparities in Pharmacologic Restraint Use in Pediatric Emergency Departments

In this episode, we discuss the causes of clozapine-induced orthostasis. Although some patients may develop tolerance, it can limit titration and potentially obstruct patients from reaching the plasma level where they respond well to the medication. There are practical management strategies for orthostasis, including slow titration based on patient complaints and encouraging fluid intake, among others. Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of ClozapineManaging Clozapine-Related Orthostasis

In this episode, we discuss the potential of lavender extract, Silexan, as an alternative treatment for anxiety and insomnia with Dr. Jim Phelps. Is it truly a promising solution free from dependency and withdrawal symptoms or just an effective placebo? Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 48Effect of Anxiolytic Drug Silexan on Sleep – A Narrative Review

In this episode, we explore a common yet severe side effect of clozapine: Constipation. Why does this drug cause such drastic changes in colonic transit times, and how can we manage it effectively? Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of ClozapineManaging Clozapine-Related Constipation

In this episode, we discuss a comprehensive study on the potential cardiovascular risks of ADHD medication. Although these medications pose minimal risk for those without preexisting conditions, there seems to be an elevated risk for those with preexisting cardiovascular diseases. Should we confidently prescribe these medications? Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about Silver and Gold memberships hereEarn 0.5 CMEs: CAP Smart Takes Vol. 09Risk of Cardiovascular Diseases Associated With Medications Used in ADHD

In this episode, we delve into the problem of sialorrhea or excessive salivation in patients on clozapine. Why does this occur, and how can it be managed? Join us as Dr. Jonathan Meyer shares his expertise on this unique side effect. Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of ClozapineManaging Clozapine-Related Sialorrhea

Can a simple lab test guide our choice of antidepressants? Explore the intriguing link between inflammation, measured by C-reactive protein (CRP) levels, and the effectiveness of certain antidepressants in this episode. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: Quick Take Vol. 48C-Reactive Protein Could Predict the Efficacy of SSRIs in Clinical Practice: A Cohort Study of Large Samples in the Real World

Could ketamine be the breakthrough we need in treating adolescent depression? Join us in this episode as we explore the potential of ketamine therapy and its rapid antidepressant effects. Also, learn how ketamine works, its safety profile, and why it's not quite ready for mainstream use in adolescents. Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D. Learn more about our membership hereEarn 0.5 CMEs: CAP Smart Takes Vol. 08Ketamine for Adolescent Depression

In this episode, we dive into the puzzling case of a 67-year-old man experiencing violent moving nightmares. Is it rapid eye movement sleep behavior disorder, frequent and recurring nightmares, night terrors, PTSD, or another parasomnia? Tune in as we explore potential diagnoses with our expert Dr. Carlos Schenck. Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D. Learn more about our memberships hereEarn 0.75 CME: Parasomnias Triggered by Antidepressant Medications: REM SleepBehavior Disorder and Restless Legs SyndromeA Clinical Case and Exclusive Videos On RBD and RLS